The Bees can be fought early on in the game and it's recommended to have your party at level 10 and have Noa and Gala in your party. The battle starts off with your character(s) being ambushed. The Killer Bees can do 100+ damage with their Poisonous Sting ability and cause the Venom status, and the Queen Bee will usually do 170+ damage with the same technique. In addition, they can all do 100+ damage with their physical combos and they are very fast.
Any accessories that block the Venom status is recommended. Seru cannot be summoned in this battle so healing spells cannot be used to get rid of status effects. Any accessories that boost ATK are recommended for this fight in order to kill individual bees faster and lessen the bee group's total damage output each turn.
The Queen Bee should be taken out right away by having all three party members target it with Hyper Arts. The Queen Bee should survive the first attack, but the second character should kill it. Gala will focus his Hyper Art attack on one of the Killer Bees if Vahn or Noa has taken out the Queen Bee, but his Hyper Art should kill it in one turn. After those two bees are down, Spirit the next turn with everybody. The following turn, use Hyper Arts again to take out the remaining two Killer Bees.